Florfenicol is a broad-spectrum antibiotic, which has a good inhibitory effect on Gram-positive bacteria and negative bacteria. Therefore, many pig farms frequently use florfenicol to prevent or treat pigs in the case of frequent diseases. sick. The veterinary staff of some pig farms use super-dose of florfenicol to treat or prevent diseases regardless of the disease, regardless of the group or stage. Florfenicol is not a panacea, and it needs to be used reasonably to achieve the desired effect. Below we introduce the common sense of the use of florfenicol in detail, hoping to be helpful to the majority of pig farmers:
1. Antibacterial properties of florfenicol
1. It has a very broad antibacterial spectrum, and has a strong killing effect on Gram-positive bacteria and negative bacteria, as well as anaerobic Gram-positive bacteria and negative spirochetes, rickettsia, amoeba, etc. Strong antibacterial effect.
2. In vitro and in vivo experiments show that its antibacterial activity is significantly better than the current antibacterial drugs.
3. Quick-acting, florfenicol can reach therapeutic concentration in blood 1 hour after intramuscular injection, and peak drug concentration can be reached in 1.5-3 hours; long-acting, effective blood drug concentration can be maintained for more than 20 hours after one administration.
4. It can penetrate the blood-brain barrier, and its therapeutic effect on animal bacterial meningitis is incomparable with other antibacterial drugs.
5. It has no toxic and side effects when used in the recommended amount, overcomes the danger of aplastic anemia and other toxicity caused by thiamphenicol, and does not cause harm to animals and food. It is used for the infection of various parts of the body caused by bacteria in animals. Treatment, including prevention and treatment of bacterial respiratory diseases, meningitis, pleurisy, mastitis, intestinal infections and postpartum syndrome in pigs.
2. Susceptible bacteria of florfenicol
1. Pig diseases where florfenicol is preferred
This product is recommended as the drug of choice for swine pneumonia, porcine infectious pleuropneumonia and Haemophilus parasuis disease, especially for the treatment of bacteria resistant to fluoroquinolones and other antibiotics.
2. Florfenicol can also be used for the treatment of the following pig diseases
It can also be used to treat respiratory diseases caused by various Streptococcus (pneumonia), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (swine asthma), etc.; salmonellosis (piglet paratyphoid), colibacillosis (piglet asthma) Digestive tract diseases such as enteritis caused by yellow diarrhea, white diarrhea, piglet edema disease) and other sensitive bacteria. Florfenicol can be used for the treatment of these swine diseases, but it is not the drug of choice for these swine diseases, so it should be used with caution.
3. Improper use of florfenicol
1. The dose is too large or too small. Large doses are poisonous, and small doses are ineffective.
2. the time is too long. Some long-term high-dose use of drugs without restraint.
3.the use of objects, stage errors. Pregnant sows and fattening pigs use such drugs indiscriminately, causing poisoning or drug residues, resulting in unsafe production and food.
4. Improper compatibility. Some people often use florfenicol in combination with sulfonamides and cephalosporins. Whether it is scientific and reasonable is worth exploring.
5. The mixed feeding is not evenly stirred, resulting in no effect of the drug or drug poisoning.
Fourth, the use of florfenicol precautions
1. This product should not be used in combination with macrolides, lincosamides and diterpenoid semi-synthetic antibiotics – Tiamulin, which can produce antagonistic effects when used in combination.
2. This product cannot be used in combination with β-lactone amines and fluoroquinolones, because this product is a fast-acting bacteriostatic agent that inhibits bacterial protein synthesis, and the latter is a fast-acting bactericide during the reproductive period. Under the action of the former, bacterial protein synthesis is rapidly inhibited, the bacteria stop growing and multiplying, and the bactericidal effect of the latter is weakened. Therefore, when the treatment needs to exert a rapid sterilization effect, it cannot be used together.
3. This product cannot be mixed with sulfadiazine sodium for intramuscular injection. It should not be used in combination with alkaline drugs when administered orally or intramuscularly, so as to avoid decomposition and failure. It is also not suitable for intravenous injection with tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, etc., to avoid precipitation and decrease in efficacy.
4. Muscle degeneration and necrosis may be caused after intramuscular injection. Therefore, it can be injected alternately in the deep muscles of the neck and buttocks, and it is not advisable to repeat injections at the same site.
5. Since this product may have embryotoxicity, it should be used with caution in pregnant and lactating sows.
6. When the body temperature of sick pigs is high, it can be used with antipyretic analgesics and dexamethasone, and the effect is better.
7. In the prevention and treatment of porcine respiratory syndrome (PRDC), some people recommend the combination of florfenicol and amoxicillin, florfenicol and tylosin, and florfenicol and tylosin, which is inappropriate. , because from a pharmacological point of view, the two cannot be used in combination. However, florfenicol can be used in combination with tetracyclines such as doxycycline.
8. This product has hematological toxicity. Although it will not cause irreversible bone marrow aplastic anemia, the reversible erythropoiesis inhibition caused by it is more common than chloramphenicol (disabled). It is contraindicated in the vaccination period or animals with severe immunodeficiency.
9. Long-term use may cause digestive disorders and vitamin deficiency or superinfection symptoms.
10. In the prevention and treatment of swine diseases, care should be taken, and the drug should be administered in accordance with the prescribed dose and course of treatment, and should not be abused to avoid adverse consequences.
11. For animals with renal insufficiency, the dose should be reduced or the administration interval should be extended.
12. In case of low temperature, it is found that the dissolution rate is slow; or the prepared solution has precipitation of florfenicol, just a little heating (not more than 45 ℃), all can be quickly dissolved. The prepared solution is best used up within 48 hours.
It is very safe to use the appropriate dosage form according to the above introduction and refer to the recommended dosage. Individual animals may experience transient loss of appetite, reduced water intake or diarrhea, slight pain at the intramuscular injection site and slight tissue reactions, which are all normal and return to normal after stopping the drug.
Post time: Mar-28-2022