Pig respiratory disease has always been a complex disease that plagues pig farm owners. The etiology is complex, the pathogens are diverse, the prevalence is wide, and prevention and control are difficult, which brings great losses to pig farms. In recent years, pig farm respiratory diseases often present mixed infections, so we are used to call it pig farm respiratory syndrome. Common pathogens include Mycoplasma, Haemophilus parasuis, Actinobacillus pleuropneumoniae, blue ear, circovirus and swine flu.
For the prevention and treatment of respiratory diseases, tilmicosin has a good effect
The respiratory pathogens of pigs are mainly divided into bacteria, viruses and mycoplasma. For mycoplasma and porcine infectious pleuropneumonia, the current conventional antibiotics have developed resistance, and a new generation of antibiotics is generally adopted clinically to prevent and treat swine respiratory diseases. For example, tilmicosin, doxycycline, tyvalomycin, etc., together with antiviral traditional Chinese medicine, have a significant effect. Studies have shown that tilmicosin has a partial antiviral effect, and it has a good effect on the control of porcine respiratory disease syndrome associated with porcine PRRS.
Tilmicosin has a deep process and has many benefits of double-layer coating.
As we all know, tilmicosin is one of the most effective drugs for controlling respiratory diseases in pig farms. However, the effects of various tilmicosin on the market are uneven. Why is this? How can we distinguish between them? What about the difference? For tilmicosin, the raw materials are almost the same, and there is not much difference. To reflect the product effect, it mainly depends on its manufacturing process. In the product manufacturing process, striving for better product effect has become the mainstream. development trend.
High-quality tilmicosin should have four characteristics: pigs love to eat, gastric protection, intestinal dissolution and slow release.
01
Distinguish from appearance
1. The uncoated tilmicosin particles are very fine and easy to dissolve at room temperature, while the coated tilmicosin particles are thicker and difficult to dissolve at room temperature.
2. Good tilmicosin (such as Chuankexin coated with double-layer microcapsules) has uniform and rounded particles. In general, the particles of tilmicosin coated vary in size and uniformity.
Distinguish from the taste in the mouth (good palatability)
Tilmicosin tastes bitter, and the uncoated tilmicosin is not suitable for oral administration. Tilmicosin with a bitter taste in the mouth not only achieves an undesired drug concentration, but also seriously affects the feed intake of pigs and causes huge damage. Drug waste.
Distinguish from gastric solubility and enteric solubility
1. The coating of tilmicosin is divided into enteric (acid-resistant but not alkali-resistant) coating and gastric-soluble (not acid- and alkali-resistant) coating. Gastric-soluble (not resistant to acid and alkali) coated tilmicosin will be dissolved and released by gastric acid in the stomach, and when the drug is released, it will stimulate the gastric mucosa to secrete gastric juice, and excessive gastric juice can easily cause gastric bleeding and gastric ulcers. If the drug is dissolved in the stomach and released in advance, the bioavailability of the drug will also be greatly reduced. Generally, the efficacy of the drug dissolved in the stomach will be reduced by more than 10% compared with that in the intestine. This significantly increases the cost of medication.
2. Enteric coating (anti-acid but not anti-alkali) The coating can be dissolved and released through the gastric acid environment insoluble in the alkaline environment of the intestine, preventing various side effects and cardiotoxic reactions caused by early release in the stomach. At the same time, the bioavailability of the drug in the intestine is improved. Fast release in the intestine.
Enteric coating uses different coating materials and processes, and the release efficiency in the intestine is also different. Ordinary coating is partially dissolved and released in the stomach cavity and gastric solution, which is very different from the effect of double-layer microcapsule coating, and the absorption rate in the intestinal tract is fast.
Post time: Mar-17-2022